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1

Discovery of potent inhibitors of interleukin-2 inducible T-cell kinase (ITK) through structure-based drug design

Brian N. Cook, Jörg Bentzien, Andre White, Peter A. Nemoto, Ji Wang, Chuk C. Man, Fariba Soleymanzadeh, Hnin Hnin Khine, Mohammed A. Kashem, Stanley Z. Kugler Jr., John P. Wolak, Gregory P. Roth, Stép

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2009

Language:

english

File:

PDF, 417 KB

english, 2009

2

Identification of a Potent Sodium Hydrogen Exchanger Isoform 1 (NHE1) Inhibitor with a Suitable Profile for Chronic Dosing and Demonstrated Cardioprotective Effects in a Preclinical Model of Myocardial Infarction in the Rat

Huber, John D., Bentzien, Jörg, Boyer, Stephen J., Burke, Jennifer, De Lombaert, Stéphane, Eickmeier, Christian, Guo, Xin, Haist, James V., Hickey, Eugene R., Kaplita, Paul, Karmazyn, Morris, Kemper,

Journal:

Journal of Medicinal Chemistry

Year:

2012

Language:

english

File:

PDF, 765 KB

english, 2012

3

Trifluoromethyl group as a pharmacophore: Effect of replacing a CF3 group on binding and agonist activity of a glucocorticoid receptor ligand

Raj Betageri, Yan Zhang, Renee M. Zindell, Daniel Kuzmich, Thomas M. Kirrane, Jörg Bentzien, Mario Cardozo, Alison J. Capolino, Tazmeen N. Fadra, Richard M. Nelson, Zofia Paw, Daw-Tsun Shih, Cheng-Kon

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2005

Language:

english

File:

PDF, 418 KB

english, 2005

4

2-Aminobenzimidazoles as potent ITK antagonists: trans-stilbene-like moieties targeting the kinase specificity pocket

Ho Yin Lo, Jörg Bentzien, Roman W. Fleck, Steven S. Pullen, Hnin Hnin Khine, Joseph R. Woska Jr., Stanley Z. Kugler, Mohammed A. Kashem, Hidenori Takahashi

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2008

Language:

english

File:

PDF, 202 KB

english, 2008

5

5-Aminomethylbenzimidazoles as potent ITK antagonists

Doris Riether, Renée Zindell, Jennifer A. Kowalski, Brian N. Cook, Jörg Bentzien, Stéphane De Lombaert, David Thomson, Stanley Z. Kugler Jr., Donna Skow, Leslie S. Martin, Ernest L. Raymond, Hnin Hnin

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2009

Language:

english

File:

PDF, 527 KB

english, 2009

6

2-Aminobenzimidazoles as potent ITK antagonists: de novo design of a pyrrole system targeting additional hydrogen bonding interaction

Ho Yin Lo, Jörg Bentzien, Andre White, Chuk C. Man, Roman W. Fleck, Steven S. Pullen, Hnin Hnin Khine, Josephine King, Joseph R. Woska Jr., John P. Wolak, Mohammed A. Kashem, Gregory P. Roth, Hidenori

Journal:

Tetrahedron Letters

Year:

2008

Language:

english

File:

PDF, 252 KB

english, 2008

7

DemQSAR: predicting human volume of distribution and clearance of drugs

Ozgur Demir-Kavuk, Jörg Bentzien, Ingo Muegge, Ernst-Walter Knapp

Journal:

Journal of Computer-Aided Molecular Design

Year:

2011

Language:

english

File:

PDF, 660 KB

english, 2011

8

Non-steroidal dissociated glucocorticoid agonists: indoles as A-ring mimetics and function-regulating pharmacophores

Raj Betageri, Thomas Gilmore, Daniel Kuzmich, Thomas M. Kirrane, Jörg Bentzien, Dieter Wiedenmayer, Younes Bekkali, John Regan, Angela Berry, Bachir Latli, Alison J. Kukulka, Tazmeen N. Fadra, Richard

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2011

Language:

english

File:

PDF, 933 KB

english, 2011

9

Crowd computing: using competitive dynamics to develop and refine highly predictive models

Bentzien, Jörg, Muegge, Ingo, Hamner, Ben, Thompson, David C.

Journal:

Drug Discovery Today

Year:

2013

Language:

english

File:

PDF, 350 KB

english, 2013

10

Function-regulating pharmacophores in a sulfonamide class of glucocorticoid receptor agonists

Kuzmich, Daniel, Bentzien, Jörg, Betageri, Raj, DiSalvo, Darren, Fadra-Khan, Tazmeen, Harcken, Christian, Kukulka, Alison, Nabozny, Gerald, Nelson, Richard, Pack, Edward, Souza, Donald, Thomson, David

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2013

Language:

english

File:

PDF, 913 KB

english, 2013

11

Discovery of a potent and dissociated non-steroidal glucocorticoid receptor agonist containing an alkyl carbinol pharmacophore

Razavi, Hossein, Riether, Doris, Harcken, Christian, Bentzien, Jörg, Dinallo, Roger M., Souza, Donald, Nelson, Richard M., Kukulka, Alison, Fadra-Khan, Tazmeen N., Pack, Edward J., Zuvela-Jelaska, Lji

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2014

Language:

english

File:

PDF, 1.08 MB

english, 2014

12

Substituted phenyl as a steroid A-ring mimetic: Providing agonist activity to a class of arylsulfonamide nonsteroidal glucocorticoid ligands

DiSalvo, Darren, Kuzmich, Daniel, Bentzien, Jörg, Regan, John, Kukulka, Alison, Fadra-Khan, Tazmeen, Nelson, Richard, Harcken, Christian, Thomson, David, Nabozny, Gerald

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2013

Language:

english

File:

PDF, 1.20 MB

english, 2013

13

Quinol-4-ones as Steroid A-Ring Mimetics in Nonsteroidal Dissociated Glucocorticoid Agonists

Regan, John, Lee, Thomas W., Zindell, Renée M., Bekkali, Younes, Bentzien, Jörg, Gilmore, Thomas, Hammach, Abdelhakim, Kirrane, Thomas M., Kukulka, Alison J., Kuzmich, Daniel, Nelson, Richard M., Prou

Journal:

Journal of Medicinal Chemistry

Year:

2006

Language:

english

File:

PDF, 150 KB

english, 2006

14

Crowdsourcing in pharma: a strategic framework

Bentzien, Jörg, Bharadwaj, Ragu, Thompson, David C.

Journal:

Drug Discovery Today

Year:

2015

Language:

english

File:

PDF, 1.19 MB

english, 2015

15

Clinical relevance of distortion product emissions by means of receiver operating characteristic (ROC) analysis

Steinhart, Helmut, Bohlender, Jörg E., Bentzien, Sabine, Hoppe, Ulrich

Journal:

Scandinavian Audiology

Year:

2001

Language:

english

File:

PDF, 446 KB

english, 2001

16

Automatically updating predictive modeling workflows support decision-making in drug design

Muegge, Ingo, Bentzien, Jörg, Mukherjee, Prasenjit, Hughes, Robert O

Journal:

Future Medicinal Chemistry

Year:

2016

Language:

english

File:

PDF, 2.28 MB

english, 2016

17

In silico predictions of genotoxicity for aromatic amines

Journal:

Frontiers in Bioscience

Year:

2014

Language:

english

File:

PDF, 527 KB

english, 2014